Consequences of quality of reduction on osteosynthesis complications and quality of life in elderly patients with subtrochanteric fracture. / Consecuencias de la calidad de reducción sobre complicaciones en la osteosíntesis y calidad de vida en pacientes adultos de edad avanzada con fractura subtrocantérea.

OBJECTIVE: To compare results in terms of orthopaedic complications and quality of life in elderly patients with subtrochanteric fracture treated with intramedullary nailing according to fracture reduction status. PATIENTS AND METHODS: A prospective cohort study including 90 elderly patients with subtrochanteric fractures of the femur treated with a cephalomedullary nail, with a minimum 1-year follow up. The inclusion criteria were: aged 60 years or older, without severe cognitive dysfunction and independent ambulatory capability before the fracture. We defined 3different groups in relation to fracture reduction status: good, acceptable and poor, according to modified criteria from Baumgartner et al. We compared clinical and surgical characteristics and healthy quality of life, social function and mobility according to the EQ-5D, Jensen Index and Mobility Score of Parker and Palmer questionnaires. RESULTS: We found differences in time to union, better in the good reduction group (P=.002); need for open reduction, more frequent in the good reduction group (P<.001), and in postoperative complications, more frequent in the poor reduction group (P=.001). We found no significant differences between the 3groups regarding scores in quality of life, social function and mobility. CONCLUSIONS: Reduction in subtrochanteric fractures in older people is key to obtaining better clinic and surgical results, improving time to union and decreasing surgical complications. Exposure of the focus fracture seems to be a safe manoeuvre. Quality of life had substantially deteriorated n these patients, but a there was a tendency, although not statistically significant, for it to improve in patients after good surgical reduction.

Meningioma en gestante afecta de endometriosis profunda. A propósito de un caso / Meningioma in pregnant women affected by deep endometriosis. About a case

RESUMEN El siguiente caso clínico trata de una paciente, gestante tras fecundación in vitro, afecta de endometriosis profunda. Dicha paciente debutó durante el embarazo con un síndrome del seno cavernoso con cefalea e hipoestesia facial, siendo diagnosticada tras una exploración neurológica detallada y las pruebas complementarias pertinentes de un meningioma. Por este motivo, tuvo que ser sometida a una cesárea previa al abordaje terapéutico del tumor, dado el empeoramiento clínico progresivo que se estaba produciendo. Dado que en la literatura científica la asociación entre la endometriosis y la aparición de meningiomas ya ha sido descrita, con este caso clínico intentaremos acercarnos a las posibles causas de dicha asociación, como podría ser el ambiente predominantemente estrogénico de las pacientes con endometriosis. De igual modo, abordaremos el manejo del meningioma tanto dentro como fuera del embarazo, sirviéndonos para ello de la bibliografía disponible.

ABSTRACT A pregnancy woman affected by deep endometriosis is presented in this clinical case. A cavernous sinus syndrome was diagnosed during her pregnancy. She started suffering from headache and facial hypoesthesia. After a detailed neurological examination and the relevant complementary tests the patient was diagnosed of a meningioma. Given the progressive clinical worsening that was taking place, she had to undergo a cesarean section prior to the therapeutic approach of the tumor. Through this clinical case we will try to approach the possible causes of the association between endometriosis and meningioma, such as the predominantly estrogenic environment of patients with endometriosis. Similarly, we will address the management of meningioma both inside and outside of pregnancy, using the related available literature.

Influencia de la asistencia a guarderías en la frecuentación en Urgencias y Atención Primaria / Influence of nursery attendance in Emergency and Primary Care frequentation

Introducción: las guarderías surgen para atender una necesidad social, pero no están exentas de influir sobre la salud infantil. Pacientes y métodos: estudio longitudinal prospectivo de dos cohortes de niños entre 0 y 24 meses (se diferencian en asistencia o no a guardería) que acuden a las consultas de 33 pediatras del Servicio Público de Salud del Principado de Asturias. Los datos se obtuvieron de la historia clínica informatizada y entrevistas programadas (6, 12, 18 y 24 meses). Se compararon: número medio de visitas a Servicios de Urgencias y Pediatría e influencia de diferentes variables recogidas. Se analizaron: la morbilidad registrada (infecciones agudas y sibilancias recurrentes) entre hiperfrecuentadores (HF) y no HF. Resultados: el número medio de visitas a las consultas pediátricas es significativamente mayor para los niños que acuden a guardería en todos los tramos de edad estudiados. Hay mayor porcentaje de HF entre los que acuden a guardería: los niños de entre 0 y 6 meses que acuden tienen un riesgo relativo de ser HF a Servicios de Urgencias de hasta seis veces mayor que los que no acuden y cuatro veces mayor de ser HF en las consultas de Pediatría. Conclusiones: 1) la asistencia a guardería se asocia con mayor probabilidad de ser HF en Urgencias y en la consulta de Pediatría de Atención Primaria (AP); 2) los niños HF padecen más enfermedades respiratorias e infecciosas, que no son explicadas por su asistencia a guardería, y 3) lo anterior conlleva un mayor consumo de fármacos (AU)

Introduction: nurseries arise to attend a social need, but are not without influence on children’s health. Patients and methods: prospective longitudinal study of two cohorts of children aged 0-24 months (they differ in nursery assistance or not) who come to the consultations of 33 pediatricians at the Public Health Service of Asturias. The data were obtained from the clinical history and interviews scheduled (6, 12, 18 and 24 months). They were compared: average number of visits to Emergency and Paediatrics Services, and influence of different variables collected. We analyzed: the registered morbidity (acute infections and recurrent wheezing) between frequent attenders (HF) and not HF. Results: the average number of visits to pediatric visits is significantly higher for children attending kindergarten in all age groups studied. There is a higher percentage of HF among those attending nursery: children between 0 and 6 months that have a relative risk of HF to Emergency Services up to 6 times higher than those not attending and four times higher of being HF in consultations of a Primary Care center. Conclusions: 1) attendance at kindergarten is associated with increased probability of being HF in Emergency departments and Paediatrics Primary Care services; 2) the HF children suffer more respiratory and infectious diseases, which are not explained by their attendance at a nursery, y 3) the above carries a higher drug consumption (AU)

Uso de anticatarrales en menores de 14 años en consultas de Atención Primaria / Use of cold and cough medications prescribed in Primary Care clinics for children less than 14 years

OBJETIVO: Conocer el perfil de prescripción de anticatarrales en las consultas de Pediatría de Atención Primaria en el Área V del Servicio de Salud del Principado de Asturias y valorar su idoneidad. Material y métodos; Estudio transversal, descriptivo y retrospectivo. Se analizaron las prescripciones para el tratamiento de los procesos respiratorios en 6 consultas de Pediatría de Atención Primaria en el Área Sanitaria V del Servicio de Salud del Principado de Asturias en el año 2011. Se valoraron la idoneidad de los tratamientos prescritos mediante las fichas técnicas de los fármacos y las indicaciones clínicas según el diagnóstico, siguiendo las recomendaciones de guías clínicas, protocolos o en su defecto la bibliografía disponible más actual. RESULTADOS: Se analizaron 424 anticatarrales: 249 antitusígenos, 155 mucolíticos y 20 clasificados en otros. La media de edad de los pacientes es de 5 años. Un 85,1% de las prescripciones se consideran inadecuadas. El 11,6% de ellos fueron prescritos fuera de ficha técnica. Se consideraron inadecuados el 82,8% de los asociados al diagnóstico R74 y el 73% al R05. Todos los fármacos de los menores de 6 años se consideraron inadecuados. El 99,4% de los mucolíticos/otros y el 75,1% de los antitusígenos se consideraron inadecuados. CONCLUSIONES: Se observa un alto porcentaje de prescripción de fármacos anticatarrales en menores de 14 años en nuestro medio, encontrándose un 85% de las prescripciones inadecuadas. Los niños deberían recibir solo medicamentos con una relación beneficio-riesgo favorable; para ello es necesario mejorar la información sobre el uso pediátrico y promover acciones formativas dirigidas a los padres y a los profesionales sanitarios

OBJECTIVE:To evaluate cold and cough medications and their suitability in children in Primary Health Care in Area V of the Asturian Health Service. MATERIAL AND METHODS: A cross-sectional, descriptive and retrospective study was conducted in which an analysis was performed of the respiratory diseases and the prescriptions of 6 Primary Health Care paediatricians who worked in Area V of the Asturian Health Service in 2011. An evaluation was made on the suitability of these medications. An analysis was also made of the drug datasheet and clinical recommendations (clinical guidelines, protocols or reports). RESULTS: A total of 424 cold and cough drugs: 249 antitussives, 155 mucolytics, and 20 'others' were analyzed. The mean age was 5 years old. There was a total of 85.1% unsuitable prescriptions. Off-label drugs were used in 11.6%. The prescribing was considered unsuitable in 82.8% of prescriptions associated with R74, and 73% of R05. All of the prescription drugs in children under 6 years old were unsuitable. Mucolytics/'others' were not suitable in 99.4%, nor antitussives in 75.1%. CONCLUSIONS: There is a high level of cold and cough drugs being prescribed in children, with 85% of these being unsuitable. Children should only receive drugs with a good risk and benefit ratio. Pediatricians should try to improve the information about pediatric drug use and spread this information to parents, doctors and nurses

[Use of cold and cough medications prescribed in Primary Care clinics for children less than 14 years]. / Uso de anticatarrales en menores de 14 años en consultas de Atención Primaria.

OBJECTIVE: To evaluate cold and cough medications and their suitability in children in Primary Health Care in Area V of the Asturian Health Service. MATERIAL AND METHODS: A cross-sectional, descriptive and retrospective study was conducted in which an analysis was performed of the respiratory diseases and the prescriptions of 6 Primary Health Care paediatricians who worked in Area V of the Asturian Health Service in 2011. An evaluation was made on the suitability of these medications. An analysis was also made of the drug datasheet and clinical recommendations (clinical guidelines, protocols or reports). RESULTS: A total of 424 cold and cough drugs: 249 antitussives, 155 mucolytics, and 20 "others" were analyzed. The mean age was 5 years old. There was a total of 85.1% unsuitable prescriptions. Off-label drugs were used in 11.6%. The prescribing was considered unsuitable in 82.8% of prescriptions associated with R74, and 73% of R05. All of the prescription drugs in children under 6 years old were unsuitable. Mucolytics/"others" were not suitable in 99.4%, nor antitussives in 75.1%. CONCLUSIONS: There is a high level of cold and cough drugs being prescribed in children, with 85% of these being unsuitable. Children should only receive drugs with a good risk and benefit ratio. Pediatricians should try to improve the information about pediatric drug use and spread this information to parents, doctors and nurses.

Enfermedad infecciosa y consumo de recursos sanitarios en menores de 2 años que acuden a guarderías / Infectious diseases and use of health care resources in children less than 2 years-old who attend kindergarten

INTRODUCCIÓN Y OBJETIVOS: Los padres con frecuencia solicitan a los pediatras consejo acerca del mejor sistema para el cuidado de sus hijos. En la literatura existen discrepancias al respecto. El objetivo de este estudio es evaluar la influencia de la asistencia a la guardería sobre el riesgo de infecciones agudas y la utilización de recursos sanitarios en los niños menores de 24 meses. Población y métodos: Estudio longitudinal prospectivo de 2 cohortes de niños de 0-24 meses que se diferencian por la asistencia o no a la guardería, nacidos entre el 1 de enero y el 30 de septiembre de 2010 y que acuden habitualmente a las consultas de 33 pediatras del Servicio Público de Salud del Principado de Asturias. RESULTADOS Y CONCLUSIONES: Se estudiaron 975 niños. A los 24 meses acuden a la guardería el 43,7%. Asistir a guardería incrementa el riesgo de padecer neumonía en un 131%, el de sibilancias recurrentes en un 69%, el de bronquitis un 57% y el de otitis media en un 64%. La exposición temprana a la guardería incrementa el riesgo de neumonías de 2,31 a 2,81 y la media de visitas a urgencias desde 1 a 2,3. La media de ciclos de antibióticos es de 1,7 para los que no van a la guardería, de 3,4 si la inician en los 6 primeros meses y de 2 si comienzan a partir de los 18 meses. La asistencia a guarderías es un factor de riesgo de padecer enfermedades infecciosas que aumenta si asisten desde edades tempranas

INTRODUCTION AND OBJECTIVES: Parents often ask paediatricians for advice about the best way to care for their children. There are discrepancies in the literature on this subject. The objective of this study is to evaluate the influence of attending kindergartens on the risk of acute infections and the use of health care resources in children less than 24 months. Population and methods: A prospective longitudinal study was conducted on two cohorts of children 0-24 months (born between 1 January and 30 September 2010), who were grouped according to whether they attended kindergarten or not, and were usually seen in 33 pediatric clinics of the Principality of Asturias Public Health Service. RESULTS AND CONCLUSIONS: A total of 975 children were studied, of whom 43.7% attended a kindergarten at 24 months. Attending kindergarten increases the risk of pneumonia by 131%, recurrent wheezing by 69%, bronchitis by 57%, and otitis media by 64%. Early exposure to kindergarten increases the risk of pneumonia from 2.31 to 2.81, and the mean emergency room visits from 1 to 2.3. The mean antibiotic cycle is 1.7 in children who do not go to kindergarten, 3.4 if started within the first 6 months, and 2 if they start at 18 months. Day-care attendance is a risk factor of infectious diseases that increases if attending kindergartens from an early age

[Infectious diseases and use of health care resources in children less than 2 years-old who attend kindergarten]. / Enfermedad infecciosa y consumo de recursos sanitarios en menores de 2 años que acuden a guarderías.

INTRODUCTION AND OBJECTIVES: Parents often ask paediatricians for advice about the best way to care for their children. There are discrepancies in the literature on this subject. The objective of this study is to evaluate the influence of attending kindergartens on the risk of acute infections and the use of health care resources in children less than 24 months. POPULATION AND METHODS: A prospective longitudinal study was conducted on two cohorts of children 0-24 months (born between 1 January and 30 September 2010), who were grouped according to whether they attended kindergarten or not, and were usually seen in 33 pediatric clinics of the Principality of Asturias Public Health Service. RESULTS AND CONCLUSIONS: A total of 975 children were studied, of whom 43.7% attended a kindergarten at 24 months. Attending kindergarten increases the risk of pneumonia by 131%, recurrent wheezing by 69%, bronchitis by 57%, and otitis media by 64%. Early exposure to kindergarten increases the risk of pneumonia from 2.31 to 2.81, and the mean emergency room visits from 1 to 2.3. The mean antibiotic cycle is 1.7 in children who do not go to kindergarten, 3.4 if started within the first 6 months, and 2 if they start at 18 months. Day-care attendance is a risk factor of infectious diseases that increases if attending kindergartens from an early age.

Influencia de la asistencia a guarderías sobre la morbilidad en niños menores de 12 meses de edad / Influence of day care attendance on morbidity in children under 12 months of age

Introducción: la estructura actual de la sociedad española favorece la asistencia de los niños a guarderías infantiles a edades cada vez más tempranas. Esto es un factor de riesgo por sí solo para el padecimiento de infecciones del tracto respiratorio superior e inferior, otitis media aguda, infecciones gastrointestinales y otras infecciones. Objetivo: evaluar la influencia de la asistencia a la guardería sobre el riesgo de padecer infecciones en los niños menores de 12 meses de edad. Población y métodos: estudio longitudinal prospectivo. Se incluyeron en el estudio los niños nacidos entre el 1 de enero y el 30 de septiembre de 2010 que acuden a consulta de Pediatría de Atención Primaria. Se excluyeron los niños que presentaban patología respiratoria o cardiaca grave o inmunodeficiencias graves. Los datos se obtuvieron de la historia clínica informatizada y de las entrevistas en visitas programadas a los padres a los 6 y a los 12 meses. Para el análisis estadístico de los datos se utilizó el programa estadístico R® (R Development Core Team, 2011). Resultados: los niños que acuden a la guardería presentan más episodios infecciosos que los que no lo hacen, siendo estadísticamente significativas (p-valor <0,05) las diferencias respecto a bronquiolitis, bronquitis, conjuntivitis, faringoamigdalitis, gastroenteritis aguda, laringitis, neumonía, otitis media aguda, resfriado común, sibilancias, sinusitis y para el total de patologías. Los niños que asisten a guarderías tienen un riesgo dos o más veces mayor de padecer bronquiolitis, bronquitis, faringoamigdalitis y otitis media, que los que no acuden. Conclusión: teniendo en cuenta estos resultados, parece aconsejable intentar otras fórmulas diferentes para el cuidado de los niños en edades tempranas (AU)

Introduction: the current structure of Spanish society favors the attendance of children at day care to increasingly early ages. This is a risk factor in itself to the condition of infection of the upper and lower respiratory tract, as well as acute otitis media, gastrointestinal infections and other infections. Objective: to evaluate the influence of day care attendance on the risk of infections in children under 12 months of age. Population and methods: prospective longitudinal study. Children born between 1 January and 30 September 2010, attending primary care pediatrics’ offices, were included. We excluded children who had severe respiratory or cardiac disease or severe immune deficiency. The data were obtained from computerized medical records and interviews with parents in scheduled visits at 6 and 12 months. In the statistical analysis of the data the statistical software R© (R Development Core Team, 2011) was used. Results: children who attend day care have one or more infectious episodes in higher percentages with statistically significant (p-value <0.05) differences for bronchiolitis, bronchitis, conjunctivitis, tonsillopharyngitis, acute gastroenteritis, laryngitis, pneumonia, acute otitis media, common cold, wheezing, sinusitis and for total pathologies. Attendance at nursery could be responsible for between 35% and 50% of the acute otitis, gastroenteritis, bronchiolitis and bronchitis. Conclusion: taking into account these results, it seems advisable to try other different ways for the care of children in early ages (AU)

Morphopathological features of a severe ulcerative disease outbreak associated with Tenacibaculum maritimum in cultivated sole, Solea senegalensis (L.).

This study describes morphopathologic changes in naturally infected farmed Senegalese sole affected by tenacibaculosis caused by Tenacibaculum maritimum. Macroscopic observation, in addition to light microscopy and scanning electron microscopy, was used to study the lesions. Main lesions were characterized by complete loss of epidermis and dermis, as well as extensive necrosis of muscle layers. Mild-to-moderate inflammatory response with the presence of macrophages was noted around hyaline degenerated muscle cells. Gram-negative filamentous bacteria could be detected only at the dermis. Under scanning electron microscopy, filamentous bacteria located over the scales without epithelium could be observed. These findings together with the isolation and PCR detection of the bacteria in kidney and skin tissues suggest that once the bacteria reach the dermis, probably through eroded epidermis, they are able to proliferate and produce enzymes that are responsible for the damage in the underlying tissues.

Long-term durability of response to adalimumab in Crohn's disease.

BACKGROUND: Adalimumab is an effective treatment for Crohn's disease (CD), but may also be associated with loss of response. Few reports provide insight into the durability of treatment of CD with adalimumab for periods longer than 12 months in clinical practice. AIMS: To evaluate the long-term durability of adalimumab maintenance treatment and to identify predictive factors associated with loss of response. METHODS: CD patients who initially responded to adalimumab were evaluated in a historical cohort study. Maintenance of long-term response was estimated using Kaplan-Meier analysis. Cox regression analysis was performed to identify potential predictive factors for loss of efficacy. RESULTS: In all, 380 CD patients were included (mean age, 38 years; 52% female). Of these, 43% had ileocolic CD, 50% inflammatory CD, and 41% perianal CD. Median follow-up with adalimumab was 8 months (range, 4-75 months). The annual risk of loss of response to adalimumab was 18% per patient-year of follow-up. Twenty-eight percent of patients were anti-TNF-naïve and 72% anti-TNF-experienced. The loss of efficacy was 8% per patient-year of follow-up in the anti-TNF-naïve patients and 22% in the anti-TNF-experienced group (P < 0.01). In the multivariate analysis, the presence of extraintestinal manifestations (hazard ratio [HR] = 1.7; 95% confidence interval [CI] = 1.02-2.9) and previous experience with other anti-TNF agents (HR = 2.5,95% CI = 1.2-5.3) were associated with higher risk of loss of efficacy. CONCLUSIONS: A relevant proportion of CD patients on long-term adalimumab lost response. The risk of loss of response was higher (more than 2-fold) in anti-TNF-experienced than in anti-TNF-naïve patients (22% vs. 8% per patient-year of treatment). Having extraintestinal manifestations seems to increase the risk of loss of efficacy.

The prevalence of coeliac disease is significantly higher in children compared with adults.

BACKGROUND: Some limited studies of coeliac disease have shown higher frequency of coeliac disease in infancy and adolescence than in adulthood. This finding has remained unnoticed and not adequately demonstrated. AIM: To assess whether there are age and gender differences in coeliac disease prevalence. METHODS: A total of 4230 subjects were included consecutively (1 to ≥80 years old) reproducing the reference population by age and gender. Sample size was calculated assuming a population-based coeliac disease prevalence of 1:250. After an interim analysis, the paediatric sample was expanded (2010 children) due to high prevalence in this group. Anti-transglutaminase and antiendomysial antibodies were determined and duodenal biopsy was performed if positive. Log-linear models were fitted to coeliac disease prevalence by age allowing calculation of percentage change of prevalence. Differences between groups were compared using Chi-squared test. RESULTS: Twenty-one subjects had coeliac disease (male/female 1:2.5). Coeliac disease prevalence in the total population was 1:204. Coeliac disease prevalence was higher in children (1:71) than in adults (1:357) (P = 0.00005). A significant decrease of prevalence in older generations was observed [change of prevalence by age of -5% (95% CI: -7.58 to -2.42%)]. In the paediatric expanded group (1-14 years), a decrease of coeliac disease prevalence was also observed [prevalence change: -17% (95% CI: -25.02 to -6.10)]. CONCLUSIONS: The prevalence of coeliac disease in childhood was five times higher than in adults. Whether this difference is due to environmental factors influencing infancy, or latency of coeliac disease in adulthood, remains to be demonstrated in prospective longitudinal studies.

Consultas dermatológicas en pediatría de atención primaria / Dermatology consultations in primary care pediatrics

Las consultas por problemas dermatológicos son muy frecuentes en pediatría.Material y métodos: mediante un estudio descriptivo observacional realizado durantetodo el año 2008, que analiza las consultas pediátricas por causas dermatológicas, se obtuvieronlos motivos principales de las consultas, se cuantificó la tasa de resolución de éstas enel ámbito de la Atención Primaria y se elaboró un listado de procesos dermatológicos comoguía para futuras actividades formativas en dermatología pediátrica.Resultados: de un total de 21.748 consultas, 1.323 se debieron a procesos dermatológicos(6,1%). La categoría con mayor número de diagnósticos correspondió al grupo dermatitis/eczema con 438 consultas (33%), seguida de las infecciones víricas con 352 (26%), lasinfecciones bacterianas con 128 (10%) y las zoonosis con 118 (9%). Fueron derivados 75 niños(5,7% de las consultas) al servicio de dermatología.Conclusiones: concluimos que la mayoría de procesos dermatológicos de la infancia puedenser manejados en Atención Primaria, manteniendo una estrecha colaboración con los especialistasen dermatología para aquellas situaciones precisadas por el escenario clínico (AU)

Consultations for dermatological problems are very common in pediatrics.Material and methods: descriptive observational study along 2008, that analyzes dermatologicalcauses of visits in Primary Care pediatrics; the main reasons for consultations wereobtained, the rate of resolution in Primary Care was quantified and a list of dermatologicalprocesses was obtained as a guide oriented to pediatric dermatological formation.Results: of 21,748 visits, 1,323 were due to dermatological conditions (6.1%). The diagnosticgroups were: skin infections, dermatitis-eczema, urticaria, zoonosis, hair and nail disorders,pigmentation disorders and miscellaneous. The main causes of consultation were:dermatitis/eczema (33%), viral skin infections (26%), bacterial skin infections (10%) andzoonosis (9%); 75 children (5.7%) were referred to dermatologists Conclusions: most of pediatric dermatological conditions can be assessed in Primary Careas far as close collaboration with the dermatologist is provided for those situations that theclinical scenario demands (AU)

Síndrome auriculotemporal (síndrome de Frey) en dos lactantes con presentación bilateral / Auriculotemporal nerve syndrome (Frey syndrome) in two infants with bilateral presentation

El síndrome auriculotemporal (síndrome de Frey) se caracteriza por episodios de enrojecimiento facial, sudoración o ambos, localizados en el territorio de distribución del nervio auriculotemporal, y que ocurren como respuesta a estímulos gustativos. Cuando se manifiesta en la infancia y coincide con la introducción de nuevos alimentos en lactantes, se puede llegar al diagnóstico erróneo de alergia alimentaria. Presentamos dos lactantes (de 5 y 6 meses) con enrojecimiento facial bilateral en el área temporal, extendiéndose hasta el borde oral; ambos manifestaron los síntomas inmediatamente a la toma de fruta (y posteriormente tras un tipo de golosina en uno de los niños) con desaparición de cuadro instantes después del cese de la toma. Los dos niños eran fruto de un parto eutócico. En uno de ellos, los síntomas desaparecieron antes del año, mientras que el segundo aún tiene 7 meses y presenta episodios de intensidad variable. Es conveniente reconocer este síndrome para evitar exploraciones innecesarias y restricciones dietéticas improcedentes (AU)

Patients with auriculotemporal nerve syndrome (Frey syndrome) have facial flushing, sweating, or both located along the distribution of the auriculotemporal nerve, and that occurs in response to gustatory stimuli. As the condition usually manifests during infancy with the introduction of solid food, it can lead to the misdiagnosis of food allergy by physicians unfamiliar with this syndrome. Two boys (5 and 6 months old) presented with a history of bilateral facial flushing extending from the corner of the mouth to the temporal area. Symptoms began at the moment of fruit introduction (orange, pear, apple and banana) and also with some type of candy in the first. Symptoms appeared immediate to fruit mastication and cutaneous erythema spontaneously disappeared in a few minutes after finishing fruit. Both cases had been born without instrumental delivery. In one case the symptoms disappeared before the end of the first year of age, and the second (he?s now 7 months old) has symptoms discontinuously. The recognition of this entity might avoid unnecessary referral and laboratory evaluation (AU)

Thromboelastographic tracings in retired racing greyhounds and in non-greyhound dogs.

BACKGROUND: Bleeding disorders in patients with normal coagulation test results are frequently reported in Greyhounds. The purpose of this study was to compare Greyhounds to non-Greyhounds by thromboelastography (TEG). HYPOTHESIS: TEG parameters in Greyhounds are different from those in non-Greyhounds. ANIMALS: Forty-three healthy dogs (28 Greyhounds and 15 non-Greyhounds) based on the results of physical examination, CBC, activated partial thromboplastin time, prothrombin time, fibrinogen, and platelet count. MATERIALS AND METHODS: Recalcified citrated native TEGs were performed in both groups; data were compared using Student's, Mann-Whitney, and Pearson's statistical tests. RESULTS: In Greyhounds, mean +/- SD were as follows: R-time 4.3 +/- 1.7 minutes, K-time 3.8 +/- 1.4 minutes, angle (alpha) 50.0 +/- 8.0 degrees , maximum amplitude (MA) 47.6 +/- 5.6 mm, clot strength (G) 4,647 +/- 1,097 dyn/cm2, and percent lysis at 60 minutes (LY60) 2.8 +/- 5.0%. In the non-Greyhounds they were R-time 3.7 +/- 1.6 minutes, K-time 2.5 +/- 0.9 minutes, angle 59.8 +/- 7.0 degrees , MA 53.1 +/- 5.6 mm, G 5,811 +/- 1,256 dyn/cm2, and LY60 3.1 +/- 2.5%. All parameters were significantly different between the groups, except for R-time and LY60. CONCLUSION: In Greyhounds, clotting kinetics are slower and clot strength are weaker than in non-Greyhounds, supporting the increased tendency to bleed observed after minor trauma or surgical procedures in the breed. The findings may also be attributed to blood viscosity or to the concentration of citrate in the sample (ie, Greyhounds have higher hematocrit and less plasma per unit volume).

Spectrum of gluten-sensitive enteropathy in first-degree relatives of patients with coeliac disease: clinical relevance of lymphocytic enteritis.

BACKGROUND: Limited data on a short series of patients suggest that lymphocytic enteritis (classically considered as latent coeliac disease) may produce symptoms of malabsorption, although the true prevalence of this situation is unknown. Serological markers of coeliac disease are of little diagnostic value in identifying these patients. AIMS: To evaluate the usefulness of human leucocyte antigen-DQ2 genotyping followed by duodenal biopsy for the detection of gluten-sensitive enteropathy in first-degree relatives of patients with coeliac disease and to assess the clinical relevance of lymphocytic enteritis diagnosed with this screening strategy. PATIENTS AND METHODS: 221 first-degree relatives of 82 DQ2+ patients with coeliac disease were consecutively included. Duodenal biopsy (for histological examination and tissue transglutaminase antibody assay in culture supernatant) was carried out on all DQ2+ relatives. Clinical features, biochemical parameters and bone mineral density were recorded. RESULTS: 130 relatives (58.8%) were DQ2+, showing the following histological stages: 64 (49.2%) Marsh 0; 32 (24.6%) Marsh I; 1 (0.8%) Marsh II; 13 (10.0%) Marsh III; 15.4% refused the biopsy. 49 relatives showed gluten sensitive enteropathy, 46 with histological abnormalities and 3 with Marsh 0 but positive tissue transglutaminase antibody in culture supernatant. Only 17 of 221 relatives had positive serological markers. Differences in the diagnostic yield between the proposed strategy and serology were significant (22.2% v 7.2%, p<0.001). Relatives with Marsh I and Marsh II-III were more often symptomatic (56.3% and 53.8%, respectively) than relatives with normal mucosa (21.1%; p = 0.002). Marsh I relatives had more severe abdominal pain (p = 0.006), severe distension (p = 0.047) and anaemia (p = 0.038) than those with Marsh 0. The prevalence of abnormal bone mineral density was similar in relatives with Marsh I (37%) and Marsh III (44.4%). CONCLUSIONS: The high number of symptomatic patients with lymphocytic enteritis (Marsh I) supports the need for a strategy based on human leucocyte antigen-DQ2 genotyping followed by duodenal biopsy in relatives of patients with coeliac disease and modifies the current concept that villous atrophy is required to prescribe a gluten-free diet.

Hipolipemiantes: estudio de la dispensación activa en Oficinas de Farmacia de la región sanitaria "Costa de Ponent" / No disponible

Este estudio contempla la dispensación activa a pacientes con hipercolesterolemia en el ámbito de la oficina de farmacia. Su diseño es descriptivo, multicéntrico y transversal. Han participado 19 oficinas de farmacia ubicadas en la Región Sanitaria "Costa de Ponent" del Servicio Catalán de la Salud (SCS). Se han entrevistado a pacientes que utilizan hipolipemiantes, recogiendo información sobre los datos demográficos del paciente, los relacionados con la hipercolesterolemia y su tratamiento, así como la detección de posibles problemas relacionados con los medicamentos (PRM’s) y el registro de las intervenciones farmacéuticas llevadas a cabo (AU)

This study consists of the development of pharmaceutical care in those patients affected by hypercholesteremia from the perspective of pharmacies. To that end, a descriptive, multicentrical and transversal trial has taken place in nineteen pharmacies from the "Costa de Ponent" Health Region of the Catalan Health Service. Such study inludes patient interviews focused on a questionnaire involvingd demographic data related to the patient, the pathology and their pharmacological treatment, as well as the detection of possible drug-related problems and the register of the pharmaceutical interventions carried out (AU)

Operación "Socotora": apoyo sanitario en una operación de visita y registro en la mar / "Socotora" mission: health support within a sea visit and registering operation

La situación mundial actual hace que cada vez sea más remota la posibilidad de una Guerra en el sentido clásico, pero sí favorece situaciones de conflicto, planteándose más a menudo operaciones más limitadas y concretas, tales como las que se presentan dentro del escenario posterior a la crisis del 11 de Septiembre. Se relatan las características de la misión del "BAC Patiño" dentro de la Operación "Libertad Duradera" y en especial las circunstancias que rodean al Abordaje al carguero norcoreano "SO SAN" suponiendo la primera Operación de Intercepción Marítima (MIO) no consentida, autorizada y realizada por Fuerzas Españolas, bautizada "Operación Socotora". Se hace especial hincapié en el cometido del Servicio de Sanidad durante su desarrollo, proponiendo un debate sobre las características de este Apoyo y discutiendo su idoneidad tal como es concebido y ejecutado (AU)

Salvamento de náufragos por el BAC Patiño en aguas del Golfo de Adén

El Buque de Aprovisionamiento en Combate "Patiño" tiene como misión proporcionar todo el apoyo logístico necesario a los buques de un grupo de combate. Está dotado de espacios médicos que lo convierten en un 2º Escalón Sanitario, pudiendo ejercer funciones de 3º Escalón cuando embarca Unidad Sanitaria (USANEM) completa. Encontrándose participando en la Operación Libertad Duradera dentro de la Fuerza Multinacional (TASK FORCE 150) en aguas del Golfo de Adén, se le encomienda el rescate de una embarcación a la deriva. Se embarcan 95 náufragos y 3 cadáveres de origen somalí, etíope y eritreo, siendo atendidos por los miembros del Servicio de Sanidad. Se exponen los detalles de las distintas fases: Alistamiento, Clasificación, Puesta en estado de evacuación y la posterior aeroevacuación (MEDEVAC). Se describen los procedimientos llevados a cabo y se exponen las reflexiones desde el punto de vista sanitario, en su versión netamente naval, logísticos y humanitarios, concluyéndose, acorde a los resultados, la adecuación y competencia de todos los estamentos del buque para afrontar situaciones de este tipo que exijan un alto grado de alistamiento y previsión (AU)

Importancia del trato humanitario en geriatría y enfermería geriátrica / The importance of the human touch in geriatrics and geriatrical treatment/care

Con el presente trabajo se pretende remarcar la importancia que tiene el trato humano en la atención de nuestros pacientes, tanto los de edad avanzada, a los que se refiere este estudio, como a los de cualquier edad. Es obvio que una atención fría, seca, áspera, agria, etc., en una palabra, deshumanizada, no va a contribuir a desarrollar otros potenciales de curación, más bien los anulan, que puedan tener nuestros ancianos, que en la mayoría de los casos, por pérdida de sus facultades físicas y psíquicas, deterioro de su rol familiar y socio-económico, están faltos o deficitarios de todo lo contrario, a saber, entrega, apoyo, cariño, alegría,optimismo, compañía, en una palabra humanidad. Hacemos una visión, con comentarios y posibles consecuencias a tener en cuenta, del tema tratado. (AU)

Contribución al estudio del tema de los accidentes y caídas en las personas mayores / A contribution to the study of accidents and falls among the aged

Hacemos en el presente trabajo un estudio y análisis del tema de los accidentes y caídas en los ancianos, que cada vez van progresivamente aumentando su incidencia, al ir paralelo al aumento de la edad media de vida o esperanza de vida al nacer, sobre todo en los países desarrollados, por los distintos factores que se hacen presente en el entorno de la persona mayor que facilitan los mismos. El tema cobra actual importancia, siendo objeto de innumerables comunicaciones, ponencias en congresos, mesas redondas y libros sobre estos temas, o capítulos en los mismos sobre ello, tanto libros de tipo sanitario (medicina, enfermería, fisioterapia, etc) como de otros campos y ramas del saber (sociología, arquitectura, ingienería, educación, legislación, tráfico, etc.) Los accidentes y caídas van a tener graves consecuencias de todo tipo sobre el anciano, la principal es la muerte como causa directa o indirecta del mismo, o bien invalideces si sobrevive al mismo. Igualmente repercusiones de todo tipo en la familia del anciano, y también repercusiones de asistencia sanitaria, sociales y económicas. Hacemos una introducción haciendo un remarque de las características primordiales de este importantísimo tema, señalando que en potencia los accidentes nos pueden afectar a todo el mundo. Acabamos con las conclusiones y al final la referencia bibliográfica (AU)